About this product

Product Identifiers

PublisherOxford University Press, Incorporated

ISBN-100195112393

ISBN-139780195112399

eBay Product ID (ePID)398819

Product Key Features

Number of Pages384 Pages

Publication NameTranscription Factors and Human Disease

LanguageEnglish

Publication Year1998

SubjectLife Sciences / Genetics & Genomics, Oncology, Genetics

TypeTextbook

Subject AreaScience, Medical

AuthorGregg L. Semenza

SeriesOxford Monographs on Medical Genetics Ser.

FormatHardcover

Dimensions

Item Height1.2 in

Item Weight31.7 Oz

Item Length9.4 in

Item Width6.2 in

Additional Product Features

Intended AudienceScholarly & Professional

LCCN97-047791

Dewey Edition21

Reviews"This book has many strengths. It is very weel written in a clear, persuasive style. The enthusiam and depth of knowledge that Gregg Semenza has for his subject is evident in every chapter.... The referencing is also very well judged, being both selective and comprehensive." --HumanGenetics, "The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough...."--CELL, "...this book will be very useful to two diverse audiences. Clinicians will be stimulated by the many examples and suggestions provided, and hopefully will look at their patients who have congenital and hereditary defects from a different perspctive. Molecular biologists will be intrigued bythe transcriptional phenomena hidden behind a particular phenotype. This book represents an important example of how medical sciences and molecular biology may interact profitably."--Nature Medicine, "This book has many strengths. It is very weel written in a clear, persuasive style. The enthusiam and depth of knowledge that Gregg Semenza has for his subject is evident in every chapter.... The referencing is also very well judged, being both selective and comprehensive." --Human Genetics"...this book will be very useful to two diverse audiences. Clinicians will be stimulated by the many examples and suggestions provided, and hopefully will look at their patients who have congenital and hereditary defects from a different perspctive. Molecular biologists will be intrigued by the transcriptional phenomena hidden behind a particular phenotype. This book represents an important example of how medical sciences and molecular biology may interactprofitably."--Nature Medicine"The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough...."--CELL, "...this book will be very useful to two diverse audiences. Clinicianswill be stimulated by the many examples and suggestions provided, and hopefullywill look at their patients who have congential and hereditary defects from adifferent perspctive. Molecular biologists will be intrigued by thetranscriptional phenonmena hidden behind a particular phenotype. This bookrepresents an important example of how medical sciences and molecular biologymay interact profitably."--Nature Medicine

Series Volume NumberNo. 37

IllustratedYes

Dewey Decimal572.8/845

Table Of ContentPart I: Transcriptional Regulation1. Gene Expression and Transcriptional Regulation2. CIS-acting Transcriptional Regulatory Elements3. Trans-acting FactorsPart II: Transcriptional Pathophysiology4. Mutations in Cis-acting Transcriptional Regulatory Elements5. Mutations in Genes Encoding Transcription Factors:The Nuclear Receptor Superfamily6. Other Zinc-Finger Proteins: WT1 and GLI37. PAX Proteins8. bHLH Proteins9. Homeodomain Proteins10. HMG Domain Proteins11. POU Domain Proteins12. Other Transcriptional Factor Families13. Co-activators14. General Transcription Factors15. Somatic Cell Genetic Disease: Cancer16. Epigenetic Disease: Teratogenesis

SynopsisSeveral general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology., Transcription Factors and Human Disease presents the basic science of transcriptional regulation and the inherited human diseases attributable to mutations in DNA sequences encoding transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is discussed, as well as the effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology., Transcription factors are essential mediators of the genetic programs that control development and physiology. This exciting book presents current knowledge of transcription factors from two viewpoints. First, the basic science of transcriptional regulation is discussed. Second, inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites are described. Readers are also introduced to the involvement of transcription factors in somatic cell genetic disease (cancer) and epigenetic disease (teratogenesis)., Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses.Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.