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Novel Biosensors Using Intact Liposome Microarrays by Nikhil Kalyankar (Paperback, 2009)

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Product Information

Many of the interactions studied in the biological and biomedical sciences occur with receptors at cell membrane surfaces. Prominent examples are neurotransmitters, cytokine receptors, tyrosine kinase receptors, ligang-and voltage-gated ion channels, G protein-coupled receptors, and antibody receptors. Interactions with these receptors are of special importance not only to academics, but also to the pharmaceutical industry as almost half of the 100 best-selling drugs on the market are targeted to a membrane receptor. More than 50% of current drug targets are membrane bound.Naturally, there is a great interest in development of sensors using membrane proteins for drug discovery and high-throughput screening for detection of pathogens/toxins. This book describes protocols to array individual, intact small unilamellar vesicles (liposomes) onto chemically modified microwell substrates. These arrays can be used as biosensors using membrane proteins or receptors incorporated in the lipid bilayer of the arrayed liposomes. One of the key examples covered in this work is the use of this platform to display GM1 ganglioside receptor to detect cholera toxin in analyte solutions.

Product Identifiers

PublisherVdm Verlag

ISBN-139783639189384

eBay Product ID (ePID)15049030669

Product Key Features

Number of Pages112 Pages

LanguageEnglish

Publication NameNovel Biosensors Using Intact Liposome Microarrays

Publication Year2009

TypeTextbook

AuthorNikhil Kalyankar

Subject AreaChemical Engineering

FormatPaperback

Dimensions

Item Height229 mm

Item Weight177 g

Item Width152 mm

Additional Product Features

Country/Region of ManufactureGermany

Title_AuthorNikhil Kalyankar