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Orphan: Quest Save Children with Rare Genetic Disorders by Philip R. Reilly HCDJ
US $6.00
ApproximatelyS$ 7.76
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A book in excellent condition. Cover is shiny and undamaged, and the dust jacket is included for hard covers. No missing or damaged pages, no creases or tears, and no underlining/highlighting of text or writing in the margins. May be very minimal identifying marks on the inside cover. Very minimal wear and tear.
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Free local pickup from Woburn, Massachusetts, United States.
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Located in: Woburn, Massachusetts, United States
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eBay item number:396604681899
Item specifics
- Condition
- ISBN
- 9781621821373
About this product
Product Identifiers
Publisher
Cold Spring Harbor Laboratory Press
ISBN-10
1621821374
ISBN-13
9781621821373
eBay Product ID (ePID)
211324414
Product Key Features
Number of Pages
408 Pages
Publication Name
Orphan: the Quest to Save Children with Rare Genetic Disorders
Language
English
Publication Year
2015
Subject
Pediatrics, Life Sciences / Genetics & Genomics, Genetics, Diseases
Type
Textbook
Subject Area
Science, Medical
Format
Hardcover
Dimensions
Item Height
1.4 in
Item Weight
28.1 Oz
Item Length
6.3 in
Item Width
9.2 in
Additional Product Features
Intended Audience
Trade
LCCN
2015-009762
Reviews
A physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers. - David J. Skorton, MD, Secretary, The Smithsonian Institution A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable. - Hank Greely, Stanford Law School, an authority on public policy issues in genetics Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families. - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling. - Donald Ingber, MD,PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, "A physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers." - David J. Skorton, MD, Secretary, The Smithsonian Institution "A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable." - Hank Greely, Stanford Law School, an authority on public policy issues in genetics "Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families." - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics "Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling." - Donald Ingber, MD, PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, "A physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers." - David J. Skorton, MD, Secretary, The Smithsonian Institution "A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable." - Hank Greely, Stanford Law School, an authority on public policy issues in genetics"Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families." - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics"Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling." - Donald Ingber, MD, PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University
Dewey Edition
23
Illustrated
Yes
Dewey Decimal
618.92/0042
Table Of Content
Preface, ix Acknowledgments Introduction 1. Diet 2. The Rise of Medical Genetics 3. Blood 4. Genetic Testing: Avoiding Disease 5. Stem Cells: Creating Human Mosaics 6. Enzyme Replacement Therapy: Genetically Engineered Drugs 7. Gene Therapy: Using Viruses to Deliver Normal Genes 8. Overcoming Mutations 9. Butterfly Children: Rebuilding the Skin 10. Ligands: Turning Genes On 11. Mending Broken Proteins 12. What Is Next: Emerging Therapies 13. We Are All Orphans: Lessons for Common Diseases Bibliography Index
Synopsis
Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us., Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you can read about for the first time in this book, along with compelling stories about the physicians, scientists, and parents who have taken them on. The diseases include phenylketonuria, sickle cell anemia, dystrophic epidermolysis bullosa, X-linked hypohidrotic ectodermal dysplasia, and Friedreich's ataxia-just a few of the more than 1000 genetic disorders that are well-described and many more that are not. Many manifest in infancy. Some show up in mid-childhood, others later in childhood, and still others among adults. They touch almost every extended family. Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us.
LC Classification Number
RJ47.3.R45 2015
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