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TNF Receptor Associated Factors (TRAFs) by Hao Wu (English) Hardcover Book

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Item specifics

Condition: Brand New: A new, unread, unused book in perfect condition with no missing or damaged pages. See all condition definitionsopens in a new window or tab

ISBN-13: 9780387706290

Book Title: TNF Receptor Associated Factors (TRAFs)

ISBN: 9780387706290

Subject Area: Computers, Science, Medical

Publication Name: Tnf Receptor Associated Factors (Trafs)

Publisher: Springer New York

Item Length: 10 in

Subject: Life Sciences / Cell Biology, Life Sciences / Biochemistry, Security / General, Life Sciences / Developmental Biology, Oncology

Publication Year: 2007

Series: Advances in Experimental Medicine and Biology Ser.

Type: Textbook

Format: Hardcover

Language: English

Item Height: 0.3 in

Author: Hao Wu

Item Weight: 22 Oz

Item Width: 7 in

Number of Pages: Xix, 206 Pages

About this product

Product Identifiers

Publisher

Springer New York

ISBN-10

0387706291

ISBN-13

9780387706290

eBay Product ID (ePID)

59118019

Product Key Features

Number of Pages

Xix, 206 Pages

Publication Name

Tnf Receptor Associated Factors (Trafs)

Language

English

Publication Year

2007

Subject

Life Sciences / Cell Biology, Life Sciences / Biochemistry, Security / General, Life Sciences / Developmental Biology, Oncology

Type

Textbook

Subject Area

Computers, Science, Medical

Author

Hao Wu

Series

Advances in Experimental Medicine and Biology Ser.

Format

Hardcover

Dimensions

Item Height

0.3 in

Item Weight

22 Oz

Item Length

10 in

Item Width

7 in

Additional Product Features

Intended Audience

Scholarly & Professional

LCCN

2007-013602

Dewey Edition

Series Volume Number

597

Number of Volumes

1 vol.

Illustrated

Yes

Dewey Decimal

616.079

Table Of Content

Phylogeny of the TRAF/MATH Domain.- TRAF1 and Its Biological Functions.- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5.- TRAF3 and Its Biological Function.- TRAF4, the Unique Family Member.- Characteristics and Biological Functions of TRAF6.- Ubiquitination and TRAF signaling.- Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway.- Protein-Protein Interactions in TRAF3.- Molecular Basis for the Unique Specificity of TRAF6.- TRAF Proteins in CD40 Signaling.- TRAFs in RANK Signaling.- The LT?R Signaling Pathway.- LMP1 TRAFficking Activates Growth and Survival pathways.- Targeting TRAFs for Therapeutic Intervention.

Synopsis

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction., This book is the only literature that is entirely devoted to TNF Receptor Associated Factors (TRAFs). Almost every aspect of TRAF signaling is covered. The book is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up-to-date on the most recent advances in TRAF signal transduction.

LC Classification Number

QH573-671