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Role de l''adn primase (prim1) dans la pathogenese des cancers humains

Awesomebooksusa
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US $59.66
ApproximatelyS$ 76.65
Condition:
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eBay item number:335215511790
Last updated on Mar 18, 2025 20:58:48 SGTView all revisionsView all revisions

Item specifics

Condition
Brand New: A new, unread, unused book in perfect condition with no missing or damaged pages. See all condition definitionsopens in a new window or tab
PublishedOn
2011-04-29
Title
Role de l''adn primase (prim1) dans la pathogenese des cancers h
Artist
Not Specified
Type
Not Specified
Publication Name
Not Specified
ISBN
9786131572296

About this product

Product Identifiers

Publisher
International Book Market Service LTD.
ISBN-10
6131572291
ISBN-13
9786131572296
eBay Product ID (ePID)
166526612

Product Key Features

Book Title
Rôle De L'adn Primase Dans La Pathogénèse Des Cancers Humains
Number of Pages
80 Pages
Language
English
Publication Year
2011
Topic
Life Sciences / Biochemistry
Genre
Science
Author
Hugo Hamel
Format
Trade Paperback

Dimensions

Item Height
0.2 in
Item Weight
4.7 Oz
Item Length
9 in
Item Width
6 in

Additional Product Features

Synopsis
L'amplification de la r gion 12q13-15 est un v nement fr quent chez plusieurs maladies n oplastiques b nignes et malignes. Elle m ne souvent l'activation d'un oncog ne via la surexpression du proto-oncog ne correspondant. Plusieurs g nes ont t identifi s dans cette r gion mais les principaux candidats pour l'induction de la transformation cellulaire demeurent cdk4 et mdm2 d leur importance fonctionnelle dans la r gulation de la transition de la phase G1 S (premier point de contr le) du cycle cellulaire. Cependant, de r centes tudes cartographiques de l'amplicon 12q13-15 ont sugg r que cdk4 et mdm2 ne sont pas les prot ines principales cibl es puisque dans chacun des cas de sarcomes humains, l'amplicon n'inclut pas un ou l'autre des deux g nes. Nos tudes ont permis de cartographier un nouveau g ne dans la r gion 12q13, pr alablement identifi comme tant PRIM1 et codant pour la sous-unit catalytique de l'ADN primase, une enzyme impliqu e dans le processus de r plication de l'ADN. Nos tudes ont galement permis de d montrer que ce g ne tait amplifi dans plus de 40% des ost osarcomes humains tudi s.

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